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Selegiline 5mg


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Selegiline 5mg is a prescription medicine that’s available under multiple brand names. It is often used as a monotherapy to reduce symptoms in early Parkinson’s Disease, or alongside alternative Parkinson’s medications in later stages of the disease. Selegiline has been shown to reduce mobility problems in people diagnosed with Parkinson’s Disease, and may help to improve overall quality of life in those with the condition.

How Selegiline Works

Selegiline is a Monoamine Oxidase-B Inhibitor, which means that it prevents the enzyme from breaking down Dopamine in the body to boost natural levels of the chemical.

While Parkinson’s Disease itself is caused by nerve cell degradation, many of the symptoms – including tremors, muscle stiffness, and loss of movement – are caused by reduced Dopamine levels that stem from the loss of nerve cell activity in the brain.

Selegiline works by increasing levels of Dopamine in the brain to reduce the severity of Parkinson’s Disease symptoms, although the medicine will not cure the condition.

Selegiline Uses

Selegiline is often prescribed to treat:

  • Parkinson’s Disease

Selegiline Dosage

Selegiline should be taken as advised by your prescribing doctor. The medicine may come in capsules that are swallowed whole, or as a disintegrating tablet. It is important to take Selegiline in the correct dosage as taking too much could raise blood pressure.

Depending on the prescribed dosage, your doctor may advise you to take Selegiline either once per day or twice per day. Your dosage may be increased over time.

If taking other medications for Parkinson’s Disease, your doctor may lower the doses of these medicines during the course of Selegiline. Always check with your doctor to ensure you are taking the correct dosage, and always complete the full course.

Selegiline Side Effects

Selegiline is generally considered to be safe when taken as prescribed. However, as with many medications, some patients may experience mild side effects, including:

  • Back pain
  • Confusion
  • Constipation or diarrhoea
  • Depression
  • Dizziness
  • Dry mouth
  • Tiredness or fatigue
  • Hallucinations
  • Headaches
  • High or low blood pressure
  • Muscle cramps
  • Nasal congestion
  • Nausea
  • Sleep disorders
  • Pain in the throat

It is important for patients to read the patient information leaflet in the packaging for a full list of possible side effects from taking Selegiline. Always consult with the prescribing doctor if side effects persist. If experiencing difficulty breathing, call 999 immediately.


  1. https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/selegiline
  2. https://bnf.nice.org.uk/drug/selegiline-hydrochloride.html
  3. https://medlineplus.gov/druginfo/meds/a697046.html
  4. https://pubmed.ncbi.nlm.nih.gov/22592509/
  5. https://www.nhs.uk/conditions/parkinsons-disease/treatment/
  6. https://www.medicines.org.uk/emc/medicine/13200#gref

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